vx-745 has been researched along with 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one in 4 studies
| Studies (vx-745) | Trials (vx-745) | Recent Studies (post-2010) (vx-745) | Studies (6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one) | Trials (6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one) | Recent Studies (post-2010) (6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one) |
|---|---|---|---|---|---|
| 58 | 1 | 35 | 27 | 1 | 22 |
| Protein | Taxonomy | vx-745 (IC50) | 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one (IC50) |
|---|---|---|---|
| Chain A, Tyrosine-protein kinase SYK | Homo sapiens (human) | 0.041 | |
| Chain A, Tyrosine-protein kinase SYK | Homo sapiens (human) | 0.041 | |
| Chain A, Tyrosine-protein kinase BTK | Homo sapiens (human) | 0.29 | |
| Chain A, Tyrosine-protein kinase BTK | Homo sapiens (human) | 0.29 | |
| Chain A, Tyrosine-protein kinase BTK | Homo sapiens (human) | 0.29 | |
| Chain A, Tyrosine-protein kinase BTK | Homo sapiens (human) | 0.29 | |
| Chain A, Tyrosine-protein kinase BTK | Homo sapiens (human) | 0.29 | |
| Chain A, Tyrosine-protein kinase BTK | Homo sapiens (human) | 0.29 | |
| Tyrosine-protein kinase JAK2 | Homo sapiens (human) | 0.006 | |
| Tyrosine-protein kinase Lyn | Homo sapiens (human) | 0.732 | |
| Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (human) | 0.005 | |
| Dipeptidyl peptidase 4 | Rattus norvegicus (Norway rat) | 0.041 | |
| Tyrosine-protein kinase ZAP-70 | Homo sapiens (human) | 0.042 | |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | 0.167 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB | 1 |
| Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
4 other study(ies) available for vx-745 and 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
| Article | Year |
|---|---|
Navigating the kinome.
Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology | 2011 |
Comprehensive analysis of kinase inhibitor selectivity.
Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |